The emergency services were called to Shedfield, Southampton, after reports that hot oil had exploded, injuring six people on Thursday evening.
A 15-year-old girl and a man and woman in their early 40s suffered "very serious injuries" on their hands, faces and arms.
Another three people sustained minor injuries in the incident.
A spokesperson for South Central Ambulance Service said: "They all had burns of varying degrees and three were very seriously injured.
She added: "This is unusual. I have never heard of anything like this happening here before."
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