A woman has had part of her brain removed in a bid to stop crippling brain seizures which are triggered by the sound of Ne-Yo's voice.
Zoe Fennessy, 26, has an epileptic seizure within seconds of hearing his voice, making her freeze, vomit and unable to react to the world around her.
She has to wear earphones whenever she goes shopping just in case the singer's tunes are played.
And if she hears one of his song's she has to cover her ears and run away otherwise she has a seizure which can leave her exhausted for days.
Surgeons removed part of her left frontal lobe in June in a bid to stop the affliction, but it didn't work and baffled medics reckon the mum will have the condition forever.
Zoe said: "I don't dislike Ne-Yo or his music, it just dislikes me unfortunately.
"I'll be walking around the supermarket doing my food shopping and I have to put my earphones in to listen to my own music just in case it comes on.
It's the same with most shops. I have to walk in with my ear phones in at first just to make sure they don't have Ne-Yo on.
If he ever releases a greatest hits album it's going to be a nightmare.
Whenever I hear the first few beats of the song I have to drop whatever I am doing and run.
People might think it is funny - and I can laugh at it myself - but it has taken over my life. It's ruined my life."
Zoe, from Retford, Nottinghamshire, had her first seizure on New Year's Day in 2006 after a long period of sickness and doctors put it down to tiredness and stress.
But when her seizures increased to six a DAY her GP booked her in for a brain test and doctors diagnosed her with epilepsy in 2008.
But it wasn't until she heard Ne-Yo's 'Give Me Everything' featuring Pitbull - which topped the charts in May 2011 - that she had her first music-induced seizure.
"It took me a while to realise that they were being triggered by his songs, and I think it wasn't until I had heard it for about the 15th time that it finally twigged what was going on," said Zoe, who hasn't been able to work for six months.
"The song was really popular and I went to my consultant and I said 'I know this sounds extremely bizarre, but every time I hear this song I have a seizure'.
He said it was fascinating and that he had never heard anything like it, and I said that while it might be fascinating, I was really struggling - the song was everywhere at the time."
She was referred to Sheffield's Hallamshire hospital where doctors played her Ne-Yo songs and were amazed when they induced a seizure.
Her doctors notes from the time say: "We recognised a few musicogenic seizures arising from the right temporal lobe stimulated by songs sung by Neyo."
Another added: "During her admission she was listening to the radio on [her] iPhone when a specific song came on the radio that triggers her fits (Pitbull Ne-Yo - Tonight).
She called for assistance at this point and she was noted to be shaking and looking rather anxious and acting a bit confused.
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"The following day we deliberately played the song and exactly the same symptoms arose."
The music attacks got more difficult to manage as the singer became more popular with every song he released, including top ten hits 'Let's Go' and 'Turn Around' in 2012.
The 15 second seizures, which happen in her right temporal lobe, leave her 'staring blankly' and after they pass she will vomit, be very thirsty and feel extremely sleepy.
In June this year Zoe endured a six-hour long operation to remove a huge chunk of her left temporal lobe where doctors thought all her seizures may originate.
But while the number of fits were dramatically reduced, she still has a fit every time she hears Ne-Yo's voice.
She said a recent holiday to Majorca - just after the singer released his song Play Hard with David Guetta - was a 'nightmare' with the song playing in every bar.
"I have had to go up to DJs in places and say 'look can you not play Ne-Yo' and they just look at me like I'm an alien," said Zoe.
"[Doctors] are saying it could possibly be something in the tone of his voice, something like that, but it doesn't happen when I hear Usher, or people like him who have a very similar sound. It is only him, only Ne-Yo.
Our holiday this year to Majorca was a nightmare. Honestly it was like being at a Ne-Yo concert - the song was everywhere.
I had to stay in the hotel room for most of the holiday because it got so bad."
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